Does Antipsychotic Dose Reduction Lead to Better Functional Recovery in First Episode Psychosis: A Randomised Controlled Trial

Grant number: 1102394 | Funding period: 2016 - 2022

Completed

Abstract

Can a person with a first episode of psychosis, once remitted, reduce their dosage of medication and still achieve better outcomes in functioning, physical health and brain volume, than if they had stayed on traditional maintenance doses of medication? This study will examine if using a dose reduction strategy in conjunction with an evidence based suite of psychosocial interventions leads to better social and vocational recovery and improved physical health and brain volume.

Related publications (1)

Can antipsychotic dose reduction lead to better functional recovery in first-episode psychosis? A randomized controlled-trial of antipsychotic dose reduction. The reduce trial: Study protocol

A Weller, J Gleeson, M Alvarez-Jimenez, P McGorry, B Nelson, K Allott, S Bendall, C Bartholomeusz, P Koval, S Harrigan, B O'Donoghue, A Fornito, C Pantelis, G Paul Amminger, A Ratheesh, A Polari, SJ Wood, K van der El, C Ellinghaus, J Gates

2019-12-01

Antipsychotic medication has been the mainstay of treatment for psychotic illnesses for over 60 years. This has been associated wi..

University of Melbourne Researchers

Eoin Killackey

Mario Alvarez-Jimenez

Patrick McGorry

Barnaby Nelson